Solubility: Soluble in water or methanol, slightly soluble in ethanol or acetone, almost insoluble in chloroform
Boiling point: 762.6°C at 760 mmHg
Doxycycline Hcl is antibacterial spectrum is very close to Tetracycline and Terramycin, but it has better effect, be sensitive to the Staphylococcus Aureus of tetracycline-resistant, oxytetracycline, long lasting time.It is often used in Senile Chronic Bronchitis, respiratory tract infection, lung infection, acute tonsillitis, mycoplasma pneumonia, urinary tract infection, blood poisoning, bacillary dysentery, acute lymphadenitis, etc. It is very popular to Nephropathy patient because of its unobvious poisoning for kidney.
Yellow crystalline powder
a) TLC testformed
b) Color reaction with sulfuric acid
c) Chloride reaction with silver nitrate
Specific optical rotation
Between –188° and –200°
Absorbance: (353nm,E1%, 1cm)
Between 270 and 290
Light absorbing impurity:
a) The absorbance at 430nm should not be greater than 0.50
b) The absorbance at 490nm should not be greater than 0.20
c) Total mixture of α,ß–apo-oxytetracycline ≤2.0%
d) Peak on the tail of the main peak:2.0%
Not more than 50ppm
Not more than 0.5%
Not more than 2.0%
Not more than 0.4I.E./mg
Almost the same Antibacterial spectrum with tetracycline and oxytetracycline, Doxycycline Hyclate has the stronger inside and outside antibacterial effect than tetracycline.Microorganism has closely cross-resistance with Doxycycline Hyclate, and tetracycline and oxytetracycline.Good oral absorption.
1.Doxycycline Hydrochlorideis a kind of antibiotics, which has very good effect on infections caused by gram-positive cocci and negative bacilli, such as upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellular tissue inflammation, senile chronic bronchitis and so on.
2.Doxycycline Hydrochloride also can be used for treating typhus fever, scrubtyphus, mycoplasmapneumonia,etc.